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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14761
    Bentamapimod
    5+ Cited Publications

    AS 602801

    		 JNK Cancer
    Bentamapimod (AS 602801) is an ATP-competitive JNK inhibitor with IC50 of 80 nM, 90 nM, and 230 nM for JNK1, JNK2, and JNK3, respectively.
    Bentamapimod
  • HY-147081
    AS 1411

    AGRO-100

    		 Others Cancer
    AS1411 is a nucleic acid aptamer that targets nucleolin. AS1411 can deliver nanoparticles, oligonucleotides, and small molecules to cancer cells, exerting antitumor effects .
    <em>AS</em> 1411
  • HY-10109
    AS-605240
    5 Publications Verification

    		 PI3K Autophagy Cancer
    AS-605240 is a specific and orally active inhibitor of the PI3Kγ, with an IC50 of 8 nM, and a Ki of 7.8 nM.
    <em>AS</em>-605240
  • HY-13532
    AS-252424
    3 Publications Verification

    		 PI3K Cancer
    AS-252424 is a potent and selective PI3Kγ inhibitor with an IC50 of 30±10 nM.
    <em>AS</em>-252424
  • HY-11010
    AS601245
    5 Publications Verification

    		 JNK Neurological Disease Inflammation/Immunology Cancer
    AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties .
    <em>AS</em>601245
  • HY-100614
    AS1517499
    20+ Cited Publications

    		 STAT Inflammation/Immunology Cancer
    AS1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor with an IC50 of 21 nM.
    <em>AS</em>1517499
  • HY-100596
    AS1842856
    Maximum Cited Publications
    46 Publications Verification

    		 Autophagy Metabolic Disease
    AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy . AS1842856 only reduces the activity of FoxO1 by binding with it, without affecting its transcription and protein expression .
    <em>AS</em>1842856
  • HY-101946
    AS-35

    		Leukotriene Receptor Inflammation/Immunology
    AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities.
    <em>AS</em>-35
  • HY-12663
    AS2521780

    		PKC Inflammation/Immunology
    AS2521780 is a novel PKCθ selective inhibitor with an IC50 of 0.48 nM.
    <em>AS</em>2521780
  • HY-114379
    AS2717638
    1 Publications Verification

    		 LPL Receptor Inflammation/Immunology
    AS2717638 is an oral active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC50 of 38 nM for hLPA5. AS2717638 also significantly improves PGE2-, PGF2α-, and AMPA-induced allodynia .
    <em>AS</em>2717638
  • HY-18686
    AS1949490

    AS1949490 is a potent, orally active, selective SHIP2 phosphatase inhibitor with IC50 values of 0.34, 0.62, 13, >50, >50, and >50 µM for Mouse SHIP2, Human SHIP2, Human SHIP1, Human PTEN, Human synaptojanin, and Human myotubularin, respectively. AS1949490 increases the phosphorylation of Akt, glucose consumption and glucose uptake. AS1949490 activates intracellular insulin signalling pathways. AS1949490 can be used for research of diabetes .
    <em>AS</em>1949490
  • HY-126675A
    AS2863619

    		CDK STAT Inflammation/Immunology
    AS2863619 enables conversion of antigen-specific effector/memory T cells into Foxp3 + regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 inhibition of CDK8/19, which consequently activates the Foxp3 gene .
    <em>AS</em>2863619
  • HY-13531
    AS-604850
    1 Publications Verification

    		 PI3K Cancer
    AS-604850 is a potent, selective and ATP-competitive PI3Kγ inhibitor with an IC50 value of 0.25 μM and a Ki value of 0.18 μM. AS-604850 shows isoform selective inhibitor of PI3Kγ with over 30-fold selectivity for PI3Kδ and β, and 18-fold selectivity over PI3Kα, respectively .
    <em>AS</em>-604850
  • HY-103142
    AS19

    		5-HT Receptor Neurological Disease
    AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia .
    <em>AS</em>19
  • HY-123046
    AS1708727
    3 Publications Verification

    		 Autophagy Metabolic Disease Cancer
    AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively .
    <em>AS</em>1708727
  • HY-18992
    AS2444697

    AS2444697 is an orally active IRAK-4 inhibitor with an IC50 of 21 nM . AS2444697 potently inhibits human and rat IRAK-4 activity. AS2444697 exhibits renoprotective effects through anti-inflammatory action .
    <em>AS</em>2444697
  • HY-134772
    AS1810722

    		STAT Cytochrome P450 Inflammation/Immunology
    AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research .
    <em>AS</em>1810722
  • HY-107535
    AS1269574

    		GPR119 TRP Channel Metabolic Disease
    AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes .
    <em>AS</em>1269574
  • HY-118521
    AS-041164

    		PI3K Inflammation/Immunology
    AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects .
    <em>AS</em>-041164
  • HY-D0891
    NSP-AS

    		Fluorescent Dye Others
    NSP-AS is chemiluminescent acridinium substrate II and can be used in homo geneous assays .
    NSP-<em>AS</em>
  • HY-141430
    AS-85

    		Histone Methyltransferase Cancer
    AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC50=0.6 µM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the Kd value of 0.78 µM .
    <em>AS</em>-85
  • HY-141429C
    AS-99

    		Histone Methyltransferase Apoptosis Cancer
    AS-99 is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .
    <em>AS</em>-99
  • HY-108519
    AS1892802

    		ROCK Neurological Disease
    AS1892802 is a potent, orally active, and highly selective inhibitor of ROCK. The onset of antinociceptive effect of AS1892802 is as fast as those of Tramadol and Diclofenac. AS1892802 did not induce gastric irritation or abnormal behavior. AS1892802 is an attractive analgesic profile for the research of severe osteoarthritis pain .
    <em>AS</em>1892802
  • HY-146883
    As-358

    		Filovirus Infection
    As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC50s of 47.5 μM and 3.7 μM .
    <em>As</em>-358
  • HY-146883A
    As-358 hydrochloride

    		Filovirus Infection
    As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety .
    <em>As</em>-358 hydrochloride
  • HY-143221
    AS-Inclisiran sodium

    		Ser/Thr Protease Cardiovascular Disease
    AS-Inclisiran sodium is the antisense of Inclisiran. Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9. Inclisiran can be used for hyperlipidemia and cardiovascular disease (CVD) research .
    <em>AS</em>-Inclisiran sodium
  • HY-33009
    AS057278

    		Others Neurological Disease
    AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC50 value of 0.91 μM and EC50 of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia .
    <em>AS</em>057278
  • HY-150621
    AS1134900

    		Others Cancer
    AS1134900 is a highly selective, allosteric and uncompetitive NADP +-dependent malic enzyme 1 (ME1) inhibitor .
    <em>AS</em>1134900
  • HY-118388
    AS604872

    		Prostaglandin Receptor Endocrinology
    AS604872 is an orally active, potent and selective prostaglandin F2α receptor (FP) antagonist with a Ki of 35 nM in humans, 158 nM in rats and 323 nM in mice. AS604872 inhibits contractions and delays labour .
    <em>AS</em>604872
  • HY-153609
    AS-Patisiran sodium

    		Transthyretin (TTR) Small Interfering RNA (siRNA) Neurological Disease
    AS-Patisiran sodium is an antisense strand of Patisiran. Patisiran is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran can be used for the research of hereditary TTR amyloidosis .
    <em>AS</em>-Patisiran sodium
  • HY-124382
    AS1928370

    		TRP Channel Neurological Disease
    AS1928370 is a novel and central nervous system (CNS) penetrant TRPV1 antagonist and can prevent ligand-induced activation in vivo. AS1928370 is a promising agent for neuropathic pain treatment research .
    <em>AS</em>1928370
  • HY-160046
    AS2 sodium

    		Others Cancer
    AS2 sodium is an ssDNA aptamer (Kd: 0.7 nM) for prostate-specific antigen (PSA). AS2 sodium does not bind non-specifically to the anti-target and has the potential to be used in diagnostic systems for prostate cancer detection .
    <em>AS</em>2 sodium
  • HY-N8329
    AS-2077715

    		Fungal Antibiotic Infection
    AS-2077715 is an antifungal agent that shows inhibitory activity against the Trichophyton species. AS-2077715 can be obtained from the fermentation broth of Capnodium sp. 339855. AS-2077715 can be used to study fungal infections .
    <em>AS</em>-2077715
  • HY-114056
    AS115

    		Others Cancer
    AS115 is a potent and selective KIAA1363 inactivator with IC50 value of 150 nM. KIAA1363 is a 2-acetyl monoacylglycerol ether (MAGE) hydrolase that is upregulated in aggressive cancers of various tissues .
    <em>AS</em>115
  • HY-W145571
    3A-Amino-3A-deoxy-(2AS,3AS)-γ-cyclodextrin

    3A-Amino-3A-deoxy-(2AS,3AS)-gamma-cyclodextrin

    		 Biochemical Assay Reagents Others
    3A-Amino-3A-deoxy-(2AS,3AS)-γ-cyclodextrin Hydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    3A-Amino-3A-deoxy-(2<em>AS</em>,3<em>AS</em>)-γ-cyclodextrin
  • HY-W145532
    3A-Amino-3A-deoxy-(2AS,3AS)-α-cyclodextrin

    3A-Amino-3A-deoxy-(2AS,3AS)-alpha-cyclodextrin

    		 Biochemical Assay Reagents Others
    3A-Amino-3A-deoxy-(2AS,3AS)-α-cyclodextrin Hydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    3A-Amino-3A-deoxy-(2<em>AS</em>,3<em>AS</em>)-α-cyclodextrin
  • HY-W145671
    3A-Amino-3A-deoxy-(2AS,3AS)-β-cyclodextrin

    3A-Amino-3A-deoxy-(2AS,3AS)-beta-cyclodextrin

    		 Biochemical Assay Reagents Others
    3A-Amino-3A-deoxy-(2AS,3AS)-β-cyclodextrin Hydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    3A-Amino-3A-deoxy-(2<em>AS</em>,3<em>AS</em>)-β-cyclodextrin
  • HY-10982
    Amonafide
    3 Publications Verification

    AS1413

    		 Topoisomerase Cancer
    Amonafide is a topoisomerase II inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.
    Amonafide
  • HY-15314
    Ranirestat
    1 Publications Verification

    AS-3201

    		 Aldose Reductase Neurological Disease Metabolic Disease
    Ranirestat (AS-3201) potent and orally active aldose reductase (AR) inhibitor with IC50s of 11 nM and 15 nM for rat lens AR and recombinant human AR, respectively, and a Ki of 0.38 nM for recombinant human AR. Ranirestat has the potential for diabetic sensorimotor polyneuropathy treatment. Ranirestat also has a neuroprotective effect on diabetic retinas .
    Ranirestat
  • HY-101019
    Ossirene
    1 Publications Verification

    AS101
    Ossirene (AS101), an immunomodulatory tellurium compound, is a potent IL-1β inhibitor . Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene potently inhibits Caspase-1 and is used for the autoimmune diseases and certain malignancies .
    Ossirene
  • HY-121932
    Naphthol AS-BR

    		Phosphatase Others
    Naphthol AS-BR is a substrate for the histochemical demonstration of acid and alkaline phosphatase .
    Naphthol <em>AS</em>-BR
  • HY-104068
    Naphthol AS-E

    		Histone Acetyltransferase Epigenetic Reader Domain Cancer
    Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction. Naphthol AS-E directly binds to the KIX domain of CBP (Kd:8.6 µM), blocks the interaction between the KIX domain and the KID domain of CREB with IC50 of 2.26 µM. Naphthol AS-E can be used for cancer research.
    Naphthol <em>AS</em>-E
  • HY-141429A
    AS-99 TFA

    		Histone Methyltransferase Apoptosis Cancer
    AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .
    <em>AS</em>-99 TFA
  • HY-134909
    AS-136A

    		DNA/RNA Synthesis Infection
    AS-136A is an orally active non-nucleoside inhibitor of the measles virus RNA-dependent RNA polymerase (RdRp) with an IC50 of 2 µM for measles virus .
    <em>AS</em>-136A
  • HY-130767
    Naphthol AS-TR phosphate

    		Biochemical Assay Reagents Others
    Naphthol AS-TR Phosphate is a water-soluble dye commonly used as an enzyme substrate in various biochemical assays to detect alkaline phosphatase activity. Naphthol AS-TR Phosphate has unique chemical properties that allow it to be hydrolyzed by alkaline phosphatase to form a colored product that can be detected spectrophotometrically. This makes it a useful tool for monitoring enzyme activity in biological samples such as serum or urine.
    Naphthol <em>AS</em>-TR phosphate
  • HY-10403A
    (aS)-PH-797804

    		p38 MAPK Inflammation/Immunology
    (aS)-PH-797804 is a selective p38 MAPK inhibitor with IC50 values for p38 α /β of 26 nM and 102 nM, respectively. (aS)-PH-797804 has anti-inflammatory activity .
    (<em>aS</em>)-PH-797804
  • HY-137833
    Naphthol AS-BI glucuronide

    Naphthol AS-BI β-D-glucuronide

    		 Biochemical Assay Reagents Others
    Naphthol AS-BI β-D-Glucuronide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Naphthol <em>AS</em>-BI glucuronide
  • HY-100744
    AS8351

    NSC51355

    		 Histone Demethylase Cardiovascular Disease
    AS8351 (NSC51355) is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells .
    <em>AS</em>8351
  • HY-A0130
    Sulfalene

    Sulfametopyrazine; AS-18908

    		 Parasite Bacterial Antibiotic Infection
    Sulfalene (Sulfametopyrazine) is an antimalarial agent. Sulfalene is also a long-acting sulfonamide antibacterial.
    Sulfalene
  • HY-126675
    AS2863619 free base

    		CDK STAT Inflammation/Immunology
    AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3 + regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base is a potent, orally active cyclin-dependent kinase 8 (CDK8) and CDK19 inhibitor with IC50s of 0.61 nM and 4.28 nM, respectively. STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene .
    <em>AS</em>2863619 free base

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